Biochemie und Pathobiochemie: Purinabbau
Purinabbau: Alternative Darstellung (kompakt)
| ⇓ | Subst. | (⇑) | ⇓ | Subst. | (⇑) | ⇓ | Subst. | (⇑) | ⇓ | Subst. | (⇑) | Co. | Enzym | EC / EG | Erkr. |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AMP |
IMP |
XMP |
GMP |
||||||||||||
| H2O
Pi |
|
H2O
Pi |
|
H2O
Pi |
|
H2O
Pi |
|
5'-Nucleo- tidase | 3.1.3.5 Hyd | ||||||
 Adenosin
|
|||||||||||||||
| H2O
NH3 |
|
Adenosin- Deaminase | 3.5.4.4 Hyd | severe combined immuno- deficiency (SCID) | |||||||||||
Inosin |
Xanthosin |
Guanosin |
|||||||||||||
| Pi
Rib-1-P |
|
Pi
Rib-1-P |
|
Pi
Rib-1-P |
|
Purin- nucleosid- Phospho- rylase | 2.4.2.1 Tr | Ataxie m. zellu- lärem Immun- defekt | |||||||
 Hypoxanthin
|
Guanin |
||||||||||||||
| O2, H2O
O2-, 2H+ |
1.
|
H2O
NH3 |
2.
|
2) Guanin- Deaminase | 3.5.4.3 Hyd | ||||||||||
 Xanthin
|
|||||||||||||||
| O2, H2O
O2-, 2H+ |
1.
|
FAD, FeS, Mo | 1) Xanthin- Oxidase (XOD) | 1.17.3.2 Ox | Xanthin- urie I | ||||||||||
Harnsäure (Ketoform) |
⇌ Harnsäure ⇌ (Enolform) |
Harnsäure (dissoz., pK = 5,4) |
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